Guillermina

FLRT3 controls the Netrin-1 response via Robo1

Guidance molecules are normally presented to cells in an overlapping fashion, however little is known about how their signals are integrated to control the formation of neural circuits. In the thalamocortical system, the topographical sorting of distinct axonal subpopulations relies on the emergent cooperation between Slit1 and Netrin-1 guidance cues presented by intermediate cellular targets. However the mechanism by which both cues interact to drive distinct axonal responses remains unknown. Here, we show that the attractive response to the guidance cue Netrin-1 is controlled by Slit/Robo1 signaling and by FLRT3, a novel co-receptor for Robo1. Leyva-Diaz et al., Current Biology 3;24(5):494-508.