We are seeking for a highly motivated postdoctoral neuroscientist with a strong background in neuroscience to study the development and plasticity of neuronal sensory circuits in the mouse using in vivo two-photon calcium imaging and electrophysiology.
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Here we described for the first time the existence of spontaneous calcium waves that propagate across different sensory nuclei in the embryonic thalamus. Disrupting the wave pattern triggers thalamic gene expression changes and eventually alters the size of cortical areas.
Here, we used a genetic dual labeling strategy in mice to purify distinct principal sensory thalamic neurons. Subsequent genome-wide transcriptome profiling revealed genes specifically expressed in each nucleus during embryonic development. Analysis of regulatory regions of the identified genes revealed key transcription factors and networks that likely underlie the specification of individual sensory-modality TC connections.
The laboratory is looking for highly motivated postdoctoral researchers! Check it out!
FLRT3 controls the Netrin-1 response via Robo1
Guidance molecules are normally presented to cells in an overlapping fashion, however little is known about how their signals are integrated to control the formation of neural circuits. In the thalamocortical system, the topographical sorting of distinct axonal subpopulations relies on the emergent cooperation between Slit1 and Netrin-1 guidance cues presented by intermediate cellular targets. However the mechanism by which both cues interact to drive distinct axonal responses remains unknown. Here, we show that the attractive response to the guidance cue Netrin-1 is controlled by Slit/Robo1 signaling and by FLRT3, a novel co-receptor for Robo1. Leyva-Diaz et al., Current Biology 3;24(5):494-508.
